Search on: PLACENTA GROWTH FACTOR 
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Descriptor English:   Placenta Growth Factor 
Descriptor Spanish:   Factor de Crecimiento Placentario 
Descriptor Portuguese:   Fator de Crescimento Placentário 
Synonyms English:   Placenta Growth Factor, PLGF-1 Isoform
Placenta Growth Factor, PLGF-2 Isoform
Placenta Growth Factor, PLGF-3 Isoform
Placenta Growth Factor, PLGF-4 Isoform
Factor, Placenta Growth
Growth Factor, Placenta
Placenta Growth Factor, PLGF 1 Isoform
Placenta Growth Factor, PLGF 2 Isoform
Placenta Growth Factor, PLGF 3 Isoform
Placenta Growth Factor, PLGF 4 Isoform  
Tree Number:   D12.644.276.100.800.100
D12.776.780.551
Definition English:   An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer. 
History Note English:   2017 (1991) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56528 
Unique Identifier:   D000072483 

Occurrence in VHL: 		 

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